abstract：:Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) widely used in the treatment of human immunodeficiency virus type 1 (HIV-1) and is the first-choice NNRTI during pregnancy. NVP shows a sex dimorphic profile in humans with sex differences in bioavailability, biotransformation and toxicity. I...

journal_title：International journal of antimicrobial agents

authors： Usach I,Compañ P,Peris JE

更新日期：2018-05-01 00:00:00

abstract：:The efficacy and safety of intrathecal (ITH) or intraventricular (IVT) colistin in addition to intravenous (IV) colistin for meningitis and ventriculitis due to carbapenem-resistant Acinetobacter baumannii (CRAB) is unclear. In this retrospective observational study of 40 patients with post-neurosurgical meningitis an...

journal_title：International journal of antimicrobial agents

authors： Chusri S,Sakarunchai I,Kositpantawong N,Panthuwong S,Santimaleeworagun W,Pattharachayakul S,Singkhamanan K,Doi Y

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVES:We hypothesised that treatment with a tigecycline-based antimicrobial regimen for intra-abdominal infection (IAI) could be associated with lower rates of subsequent carbapenem-resistant Enterobacteriaceae (CRE) colonisation or Clostridium difficile infection (CDI) compared with a meropenem-based regimen. ME...

journal_title：International journal of antimicrobial agents

authors： Bartoletti M,Tedeschi S,Pascale R,Raumer L,Maraolo AE,Palmiero G,Tumietto F,Cristini F,Ambretti S,Giannella M,Lewis RE,Viale P

更新日期：2018-03-01 00:00:00

abstract：:This study assessed whether augmented renal clearance (ARC) impacts negatively on antibiotic concentrations and clinical outcomes in patients treated by high-dose β-lactams administered continuously. Over a 9-month period, all critically ill patients without renal impairment treated by one of the monitored β-lactams f...

journal_title：International journal of antimicrobial agents

authors： Carrié C,Petit L,d'Houdain N,Sauvage N,Cottenceau V,Lafitte M,Foumenteze C,Hisz Q,Menu D,Legeron R,Breilh D,Sztark F

更新日期：2018-03-01 00:00:00

abstract：:Recurrence of Clostridium difficile infection (CDI) has major consequences for both patients and the health system. The ability to predict which patients are at increased risk of recurrent CDI makes it possible to select candidates for treatment with new drugs and therapies (including fecal microbiota transplantation)...

journal_title：International journal of antimicrobial agents

authors： Cobo J,Merino E,Martínez C,Cózar-Llistó A,Shaw E,Marrodán T,Calbo E,Bereciartúa E,Sánchez-Muñoz LA,Salavert M,Pérez-Rodríguez MT,García-Rosado D,Bravo-Ferrer JM,Gálvez-Acebal J,Henríquez-Camacho C,Cuquet J,Pino-Calm B,T

更新日期：2018-03-01 00:00:00

abstract：:Many drugs used to treat non-infectious diseases have also shown excellent antibacterial activity or the ability to enhance the action of antibiotics. The aim of this study was to investigate the antibacterial activity of a popular β-blocker, carvedilol, and its mechanism of antibacterial action. The antibacterial act...

journal_title：International journal of antimicrobial agents

authors： Zawadzka K,Bernat P,Felczak A,Różalska S,Lisowska K

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:There are several empiric antibiotic treatment options for febrile neutropenia, yet there is no universally-accepted initial protocol. We aimed to assess the performance of a protocol (piperacillin, gentamicin and cefazolin) introduced over 40 years ago and compare its coverage against bacteria isolated from...

journal_title：International journal of antimicrobial agents

authors： Kleinhendler E,Cohen MJ,Moses AE,Paltiel O,Strahilevitz J,Cahan A

更新日期：2018-01-01 00:00:00

abstract：:A strong antistaphylococcal peptide (ASP-1) from Bacillus subtilis URID 12.1 strain that is active against cefoxitin- and methicillin-resistant Staphylococcus aureus clinical isolates was purified to homogeneity by solvent extraction, silica gel-based adsorption chromatography and reversed-phase high-performance liqui...

journal_title：International journal of antimicrobial agents

authors： Chalasani AG,Roy U,Nema S

更新日期：2018-01-01 00:00:00

abstract：:Outpatient parenteral antimicrobial therapy (OPAT) has evolved relatively slowly in the UK. This study describes the OPAT service based in a large UK teaching hospital in Sheffield, and examines the clinical efficacy, patient acceptability and costs saved over a 10-year period. Data on 3812 episodes of OPAT administer...

journal_title：International journal of antimicrobial agents

authors： Durojaiye OC,Bell H,Andrews D,Ntziora F,Cartwright K

更新日期：2018-01-01 00:00:00

abstract：:Staphylococcus aureus is responsible for life-threatening and difficult-to-treat infections worldwide and antimicrobial resistance is an increasing concern. Whilst acquired resistance has been widely studied, little is known of the contributions from chromosomal determinants that upon inactivation may reduce the susce...

journal_title：International journal of antimicrobial agents

authors： Vestergaard M,Nøhr-Meldgaard K,Ingmer H

更新日期：2018-01-01 00:00:00

abstract：:Infections caused by multidrug-resistant bacteria, including Pseudomonas aeruginosa, are threatening public health worldwide. Therefore, a novel antibacterial agent is needed to treat these infections. Here, we investigated the in vitro and in vivo activities of a novel siderophore-conjugated cephalosporin, LCB10-0200...

journal_title：International journal of antimicrobial agents

authors： Oh SH,Park HS,Kim HS,Yun JY,Oh K,Cho YL,Kwak JH

更新日期：2017-12-01 00:00:00

abstract：:Infection is the most relevant surgical complication in implant or grafting procedures. Osteomyelitis and other chronic conditions pose a constant challenge in current medical practice. In this context, a grafting biomaterial that possesses antibacterial properties combined with bioactivity could have great clinical i...

journal_title：International journal of antimicrobial agents

authors： Souza MT,Campanini LA,Chinaglia CR,Peitl O,Zanotto ED,Souza CWO

更新日期：2017-12-01 00:00:00

abstract：:Tigecycline resistance is emerging among Klebsiella pneumoniae, but knowledge regarding in vivo development of tigecycline resistance is limited. Here we report a new mechanism of tigecycline resistance in K. pneumoniae that evolved during tigecycline therapy. Klebsiella pneumoniae isolates were consecutively obtained...

journal_title：International journal of antimicrobial agents

authors： Ye M,Ding B,Qian H,Xu Q,Jiang J,Huang J,Ou H,Hu F,Wang M

更新日期：2017-10-01 00:00:00

abstract：:Invasive pulmonary aspergillosis (IPA) is an increasingly recognised problem in critically ill patients. Little is known about how intensivists react to an Aspergillus-positive respiratory sample or the efficacy of antifungal therapy (AFT). This study aimed to identify drivers of AFT prescription and diagnostic workup...

journal_title：International journal of antimicrobial agents

authors： Paiva JA,Mergulhão P,Gomes A,Taccone FS,Van den Abeele AM,Bulpa P,Misset B,Meersseman W,Dimopoulos G,Rello J,Vogelaers D,Blot S

更新日期：2017-10-01 00:00:00

abstract：:With the abuse of macrolide, lincosamide, and streptogramin (MLS), the traditionally safe bifidobacterial strains in the human intestine could serve as a reservoir of MLS resistance genes. In this study, the erm(X) gene was detected in 29 MLS-resistant strains and one MLS-susceptible strain among 92 bifidobacterial st...

journal_title：International journal of antimicrobial agents

authors： Wang N,Hang X,Zhang M,Peng X,Yang H

更新日期：2017-10-01 00:00:00

abstract：:Fluoroquinolones (FQs) are highly effective for treating tularaemia, a zoonosis caused by Francisella tularensis, but failures and relapses remain common in patients with treatment delay or immunocompromised status. FQ-resistant strains of F. tularensis harboring mutations in the quinolone-resistance determining regio...

journal_title：International journal of antimicrobial agents

authors： Sutera V,Hoarau G,Renesto P,Caspar Y,Maurin M

更新日期：2017-09-01 00:00:00

abstract：:Piperacillin-tazobactam (PIP-TAZ) is commonly used to treat intraabdominal infections; however, its penetration into abdominal sites is unclear. A pharmacokinetic analysis of plasma, peritoneal fluid, and peritoneum drug concentrations was conducted to simulate dosing regimens needed to attain the pharmacodynamic targ...

journal_title：International journal of antimicrobial agents

authors： Murao N,Ohge H,Ikawa K,Watadani Y,Uegami S,Shigemoto N,Shimada N,Yano R,Kajihara T,Uemura K,Murakami Y,Morikawa N,Sueda T

更新日期：2017-09-01 00:00:00

abstract：:The aim of this study was to develop an in-vitro topical treatment for Acanthamoeba keratitis (AK) effective against cysts and trophozoites. Qualitative assays were performed with voriconazole, chlorhexidine, propamidine, cellulase, tobramycin, ciprofloxacin and paromomycin as monotherapy and various combinations. Rib...

journal_title：International journal of antimicrobial agents

authors： Ortillés Á,Belloc J,Rubio E,Fernández MT,Benito M,Cristóbal JÁ,Calvo B,Goñi P

更新日期：2017-09-01 00:00:00

abstract：:In November 2015, the first plasmid-encoded colistin resistance gene, mcr-1, was described in animals and in humans in China. Subsequently, a multitude of further studies was performed and quite recently the global spread of mcr-1 as well as the occurrence of a new gene variant, mcr-2, was reported. To obtain an overv...

journal_title：International journal of antimicrobial agents

authors： Roschanski N,Falgenhauer L,Grobbel M,Guenther S,Kreienbrock L,Imirzalioglu C,Roesler U

更新日期：2017-08-01 00:00:00

abstract：:Advanced molecular typing methods have greatly expanded the taxonomy of Mycobacterium avium complex (MAC) species; however, little is known about the epidemiology and clinical features of bacteraemia caused by different MAC species. In this study, the clinical characteristics of patients treated for MAC bacteraemia in...

journal_title：International journal of antimicrobial agents

authors： Lee MR,Chien JY,Huang YT,Liao CH,Shu CC,Yu CJ,Hsueh PR

更新日期：2017-07-01 00:00:00

abstract：:Recent studies have found an association between piperacillin/tazobactam when added to vancomycin and acute kidney injury (AKI) risk. However, studies were limited by the small sample size and residual confounding. The aim of this study was to compare the risk of AKI with vancomycin plus piperacillin/tazobactam (VPT) ...

journal_title：International journal of antimicrobial agents

authors： Jeon N,Staley B,Klinker KP,Hincapie Castillo J,Winterstein AG

更新日期：2017-07-01 00:00:00

abstract：:In this study, the prevalence and characteristics of metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa isolates in South Korea were investigated. Among 215 P. aeruginosa isolates collected from eight hospitals, 77 (35.8%) and 72 (33.5%) were resistant to imipenem and meropenem, respectively. Of the 77 imipene...

journal_title：International journal of antimicrobial agents

authors： Wi YM,Choi JY,Lee JY,Kang CI,Chung DR,Peck KR,Song JH,Ko KS

更新日期：2017-06-01 00:00:00

abstract：:The management of some serious infections such as infective endocarditis (IE) and bone and joint infections (BJIs) caused by Gram-positive cocci (GPC) is complex and requires great responsiveness and effective antimicrobials with high bioavailability in heart valves or bone tissues. Treatment of these infections requi...

journal_title：International journal of antimicrobial agents

authors： Seng P,Amrane S,Million M,Stein A

更新日期：2017-05-01 00:00:00

abstract：:For several years, the threat of antibiotic resistance and its health cost has dramatically risen and various alarming figures have been proposed to illustrate the mortality due to antibiotic resistance. However, predictions concerning different living beings are doomed to failure, as theorised in Alice's 'living croq...

journal_title：International journal of antimicrobial agents

authors： Dubourg G,Abat C,Raoult D

更新日期：2017-05-01 00:00:00

abstract：:Norvancomycin is an antibiotic that has been approved for the treatment of infections caused by antibiotic-resistant Gram-positive bacteria and has been used in China for more than a decade. However, the cerebrospinal fluid (CSF) penetration of norvancomycin has not been evaluated. The aims of the study were (i) to in...

journal_title：International journal of antimicrobial agents

authors： Li J,He S,Yang Z,Lu C

更新日期：2017-05-01 00:00:00

abstract：:The antimicrobial activity and toxicity to nematodes of the cyclam salt [H2{H2(4-CF3PhCH2)2Cyclam}](CH3COO)2⋅(CH3COOH)2 were evaluated. Estimated minimum inhibitory concentrations (MICs) of 9, 261 and 15 µg/mL were obtained for Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, respectively. For selec...

journal_title：International journal of antimicrobial agents

authors： Alves LG,Pinheiro PF,Feliciano JR,Dâmaso DP,Leitão JH,Martins AM

更新日期：2017-05-01 00:00:00

abstract：:Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-Ec) is a frequent cause of acute pyelonephritis (APN), requiring carbapenem therapy. However, alternatives to carbapenems are needed due to the emergence of carbapenemase-producing micro-organisms. The purpose of this study was to compare the clinical effi...

journal_title：International journal of antimicrobial agents

authors： Yoon YK,Kim JH,Sohn JW,Yang KS,Kim MJ

更新日期：2017-04-01 00:00:00

abstract：:Tigecycline is highly active against various drug-resistant bacteria. The US Food and Drug Administration (FDA) recently issued a black box warning for tigecycline owing to an associated increase in all-cause mortality. Clinical breakpoints of antibiotics are vital in susceptibility testing of pathogens for the select...

journal_title：International journal of antimicrobial agents

authors： Singh RSP,Mukker JK,Drescher SK,Deitchman AN,Derendorf H

更新日期：2017-04-01 00:00:00

abstract：:Macrolides, especially clarithromycin (CLA), remain the cornerstone of therapy for Mycobacterium abscessus complex infections. The purpose of this study was to gather results from in vitro drug susceptibility testing of M. abscessus and Mycobacterium massiliense for the combination of CLA with various other agents, in...

journal_title：International journal of antimicrobial agents

authors： Zhang Z,Lu J,Liu M,Wang Y,Zhao Y,Pang Y

更新日期：2017-03-01 00:00:00

abstract：:The whole-genome sequences of 24 isolates of Neisseria gonorrhoeae with elevated minimum inhibitory concentrations (MICs) to azithromycin (≥2.0 µg/mL) were analyzed against a modified sequence derived from the whole-genome sequence of N. gonorrhoeae FA1090 to determine, by signal ratio, the number of mutant copies of ...

journal_title：International journal of antimicrobial agents

authors： Johnson SR,Grad Y,Abrams AJ,Pettus K,Trees DL

更新日期：2017-02-01 00:00:00

abstract：:Lovastatin is a prodrug that is hydrolysed in vivo to β-hydroxy acid lovastatin, which inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-Co-A) reductase (HMGR), thereby lowering cholesterol in humans. A side effect of lovastatin is inhibition of isoprenoid synthesis and cell membrane formation in methanogenic Archae...

journal_title：International journal of antimicrobial agents

authors： Demonfort Nkamga V,Armstrong N,Drancourt M

更新日期：2017-02-01 00:00:00

abstract：:The aim of this study was to screen lead compounds exhibiting potent in vitro antimicrobial activity against multidrug-resistant (MDR) Acinetobacter baumannii strains from a library of chemical compounds. In a high-throughput screening analysis of 7520 compounds representative of 340,000 small molecules, two 4H-4-oxoq...

journal_title：International journal of antimicrobial agents

authors： Na SH,Jeon H,Kim YJ,Kwon HI,Selasi GN,Nicholas A,Yun CS,Lee SH,Lee JC

更新日期：2017-01-01 00:00:00

abstract：:Antimicrobial agents (AMAs) have been used in agriculture since the 1950s as growth-promoting agents [antimicrobial growth promoters (AGPs)]. They have provided benefits to the agricultural industry by increasing production efficiencies and maximising livestock health, yet the potential risks surrounding resistance to...

journal_title：International journal of antimicrobial agents

authors： Brown K,Uwiera RRE,Kalmokoff ML,Brooks SPJ,Inglis GD

更新日期：2017-01-01 00:00:00

abstract：:The polymyxin antibiotics [colistin and polymyxin B (PMB)] are increasingly used as a last-line option for the treatment of infections caused by extensively drug-resistant Gram-negative bacteria. Despite having similar structures and antibacterial activity in vitro, the two clinically available polymyxins have very di...

journal_title：International journal of antimicrobial agents

authors： Tran TB,Velkov T,Nation RL,Forrest A,Tsuji BT,Bergen PJ,Li J

更新日期：2016-12-01 00:00:00

abstract：:Colistin has been used in veterinary medicine for decades, mainly for the prevention and treatment of Enterobacteriaceae infections. However, data regarding colistin resistance in bacteria from animals and food of animal origin are relatively scarce, partly because there are methodological difficulties hampering the a...

journal_title：International journal of antimicrobial agents

authors： Kempf I,Jouy E,Chauvin C

更新日期：2016-12-01 00:00:00

abstract：:Chemotherapy is a cornerstone of cancer treatment but it can have serious side effects, such as intestinal mucositis. This work reports the susceptibility/resistance profiles of 34 species of lactic acid bacteria (LAB), bifidobacteria and other intestinal bacteria from different collections to various chemotherapeutic...

journal_title：International journal of antimicrobial agents

authors： Flórez AB,Sierra M,Ruas-Madiedo P,Mayo B

更新日期：2016-11-01 00:00:00

abstract：:Mechanisms leading to carbapenem and cephalosporin resistance were sought in Enterobacter aerogenes isolates that were highly resistant to carbapenems but had no known carbapenemase. Results were compared with recent work examining carbapenem-resistant Enterobacter cloacae. Eighteen carbapenem-resistant E. aerogenes w...

journal_title：International journal of antimicrobial agents

authors： Babouee Flury B,Ellington MJ,Hopkins KL,Turton JF,Doumith M,Woodford N

更新日期：2016-11-01 00:00:00

abstract：:In recent years, the emergence of methicillin-resistant Staphylococcus aureus (MRSA) strains has been observed in ocular infections. Resistance of MRSA to second- and third-generation fluoroquinolones has increased interest in the fourth-generation fluoroquinolones. In this study, the antibacterial activity of gemiflo...

journal_title：International journal of antimicrobial agents

authors： Marino A,Blanco AR,Ginestra G,Nostro A,Bisignano G

更新日期：2016-10-01 00:00:00

abstract：:Therapeutic drug monitoring for critically ill patients receiving piperacillin/tazobactam is described as a useful tool. However, the minimum inhibitory concentration of piperacillin depends on a sufficiently high concentration of tazobactam in case of β-lactamase-producing strains. Therefore, the relationship between...

journal_title：International journal of antimicrobial agents

authors： Zander J,Döbbeler G,Nagel D,Scharf C,Huseyn-Zada M,Jung J,Frey L,Vogeser M,Zoller M

更新日期：2016-10-01 00:00:00

abstract：:The ongoing seventh cholera pandemic is attributed to Vibrio cholerae O1 El Tor biotype strains. Although antibiotic therapy ameliorates symptoms in patients and reduces pathogen transfer to the environment, multidrug resistance remains a major clinical threat. An O1 El Tor strain isolated from a patient in 1998 was i...

journal_title：International journal of antimicrobial agents

authors： Wang R,Li J,Kan B

更新日期：2016-09-01 00:00:00